Calcite has numerous uses as a neutralizer of acids. For hundreds of years, limestones and marbles have been crushed and spread on fields as an acid-neutralizing soil treatment. They are also heated to produce lime that has a much faster reaction rate in the soil.

Calcite is used as an acid neutralizer in the chemical industry. In areas were streams are plagued with acid mine drainage, crushed limestone is dispensed into the streams to neutralize their waters.

Calcium carbonate derived from high-purity limestones or marbles is used in medicine. Mixed with sugar and flavoring, calcium carbonate is made into chewable tablets used in the neutralization of stomach acids. It is also an ingredient in numerous medications used to treat digestive and other ailments.